Introduction
Y’all, let me tell you about the day I discovered what a real Southern meatloaf recipe should taste like. I was visiting my college roommate’s grandmother in Savannah, Georgia, and Miss Ruby served us this incredible meatloaf that had me practically licking the plate clean. I begged her for the recipe, and she just smiled and said, “Honey, it’s all about the love you put into it.” That was fifteen years ago, and I’ve been perfecting this Southern meatloaf recipe ever since.
Have you ever wondered why some meatloaves turn out dry and flavorless while others are so tender and juicy they practically melt in your mouth? Trust me, I learned the hard way – I tried this recipe seven times before getting it absolutely perfect! The secret isn’t just in the ingredients; it’s in understanding how Southern cooks have been making comfort food for generations.
This isn’t your average weeknight dinner – this is the kind of Southern meatloaf recipe that brings families together around the table, the one that makes your house smell like pure comfort, and the dish that’ll have your neighbors asking what you’re cooking. I’ve served this at everything from Sunday dinners to potluck suppers, and it never fails to get rave reviews.
Table of Contents
Ingredients List

Here’s what you’ll need for this soul-warming Southern meatloaf recipe:
For the Meatloaf:
- 2 pounds ground beef (80/20 blend – trust me on this ratio)
- 1 pound ground pork (this is the secret to Southern flavor!)
- 1 large sweet onion, finely diced
- 3 cloves garlic, minced
- 2 large eggs, beaten
- 1 cup seasoned breadcrumbs
- 1/2 cup whole milk
- 1/4 cup ketchup
- 2 tablespoons Worcestershire sauce
- 1 tablespoon brown sugar
- 2 teaspoons smoked paprika (I get mine from a spice shop in Nashville)
- 1 teaspoon dried thyme
- 1 teaspoon onion powder
- 1 teaspoon garlic powder
- 1 teaspoon salt
- 1/2 teaspoon black pepper
- 1/4 teaspoon cayenne pepper (adjust to taste)
For the Glaze:
- 1/2 cup ketchup
- 3 tablespoons brown sugar
- 2 tablespoons apple cider vinegar
- 1 tablespoon yellow mustard
- 1 teaspoon smoked paprika
Substitution Notes: If you can’t find ground pork, you can substitute with ground turkey, but you’ll lose some of that rich Southern flavor. For a lighter version, try 93/7 ground beef, but add an extra egg to keep it moist. I discovered this trick when my husband was trying to eat healthier – it still tastes amazing!
Timing
Prep Time: 20 minutes Cook Time: 1 hour 15 minutes Total Time: 1 hour 35 minutes Serves: 6-8 people
Here’s my honest timing advice: I always start this recipe about 2 hours before I want to serve dinner. This gives me time to prep without rushing (which always leads to mistakes in my kitchen!), plus it allows the meatloaf to rest for 10 minutes after cooking – something I learned the hard way when I sliced into one too early and watched all the juices run out.
This recipe is perfect for those busy weeknights when you want something comforting but don’t have hours to spend in the kitchen. I often prep the meat mixture in the morning and refrigerate it, then just shape and bake it when I get home from work.
Step-by-Step Instructions

Step 1: Prepare Your Workspace
Preheat your oven to 350°F and line a rimmed cookie sheet with parchment paper. I learned this trick from my grandmother – never use a loaf pan for meatloaf! You want the heat to circulate around the entire loaf for even cooking.
Step 2: Sauté the Aromatics
In a large skillet over medium heat, cook the diced onion until softened and translucent, about 5 minutes. Add the minced garlic and cook for another minute until fragrant. Let this cool completely – adding hot onions to raw meat is a rookie mistake I made exactly once!
Step 3: Create the Meat Mixture
In a large mixing bowl, combine the ground beef and pork. Add the cooled onion mixture, beaten eggs, breadcrumbs, milk, ketchup, Worcestershire sauce, brown sugar, and all the seasonings. Here’s where I need you to trust me: mix this with your hands, not a spoon or mixer. Your hands are the best tools for this job, and you’ll get a feel for when it’s perfectly combined without overworking the meat.
Step 4: Shape the Loaf
Transfer the mixture to your prepared cookie sheet and shape it into a loaf about 10 inches long and 5 inches wide. Make sure the top is slightly rounded – this helps it cook evenly and look beautiful when sliced.
Step 5: Prepare the Glaze
Whisk together all the glaze ingredients in a small bowl. This sweet and tangy glaze is what makes this Southern meatloaf recipe truly special. Brush half of the glaze over the top of the raw meatloaf.
Step 6: Bake to Perfection
Bake for 45 minutes, then brush with the remaining glaze and continue baking for 15-20 minutes until the internal temperature reaches 160°F. The top should be beautifully caramelized and slightly crispy.
Step 7: Rest and Serve
Let the meatloaf rest for 10 minutes before slicing. I know it’s tempting to cut right into it, but this resting time allows the juices to redistribute throughout the meat, ensuring every slice is perfectly moist.
Nutritional Information
Here’s the nutritional breakdown per serving (based on 8 servings):
- Calories: 385
- Protein: 28g
- Carbohydrates: 18g
- Fat: 22g
- Fiber: 1g
- Sugar: 12g
- Sodium: 720mg
As a food blogger who cares deeply about balanced nutrition, I love that this recipe provides substantial protein while incorporating vegetables and whole grains. The combination of beef and pork gives you a good mix of essential amino acids, and the onions add antioxidants and fiber.
The higher fat content comes from the meat blend, which is essential for flavor and moisture. If you’re watching your fat intake, you can substitute leaner meats, but remember to add an extra egg or some grated vegetables to maintain moisture.
Healthier Alternatives for the Recipe
When my sister was diagnosed with high blood pressure, I developed some heart-healthy modifications that still deliver incredible flavor:
Lower Sodium Version:
- Use low-sodium breadcrumbs and reduce salt to 1/2 teaspoon
- Replace regular ketchup with no-sugar-added version
- Use fresh herbs instead of dried (double the amounts)
Lighter Version:
- Substitute half the ground beef with finely grated zucchini and carrots
- Use 93/7 ground beef and ground turkey instead of pork
- Replace whole milk with unsweetened almond milk
- Add an extra egg white for binding
Gluten-Free Option:
- Replace breadcrumbs with almond flour or crushed gluten-free crackers
- Double-check that your Worcestershire sauce is gluten-free
Vegetable-Packed Version:
- Add 1 cup finely diced bell peppers and celery to the onion mixture
- Include 1/2 cup grated carrots for extra nutrition and natural sweetness
These modifications maintain the soul-warming comfort of the original while adapting to different dietary needs. The vegetable-packed version is actually my kids’ favorite – they get extra nutrition without even realizing it!
Serving Suggestions

This Southern meatloaf recipe shines brightest when served with classic comfort food sides. Here are my family’s absolute favorites:
Traditional Southern Sides:
- Creamy mashed potatoes with plenty of butter and cream
- Green beans slow-cooked with onions and bacon pieces
- Buttermilk cornbread with honey butter
- Mac and cheese made from scratch
Lighter Accompaniments:
- Roasted sweet potatoes with herbs
- Steamed broccoli with lemon
- Simple garden salad with ranch dressing
- Roasted Brussels sprouts with balsamic glaze
Special Occasion Pairings: I served this at my husband’s 40th birthday party alongside bourbon-glazed carrots and garlic mashed cauliflower – it was absolutely divine! For holiday meals, I love pairing it with cranberry sauce and roasted root vegetables.
Leftover Magic: The next day, slice the cold meatloaf thick and make the most incredible sandwiches with mayo, lettuce, and tomato on toasted bread. My teenagers actually fight over these leftovers!
Common Mistakes to Avoid
Let me save you from the mistakes I’ve made over the years:
Overmixing the Meat: I cannot stress this enough – mix just until combined. The first time I made this, I mixed it like I was making bread dough. The result? A dense, tough meatloaf that could have been used as a doorstop!
Using the Wrong Meat Ratio: Don’t go too lean with your ground beef. That 80/20 blend is crucial for flavor and moisture. I tried 90/10 once to be “healthy” and ended up with a dry, flavorless loaf.
Skipping the Resting Time: I know you’re hungry, but cutting into the meatloaf immediately after it comes out of the oven will cause all those beautiful juices to run out onto your cutting board instead of staying in the meat.
Cooking in a Loaf Pan: This traps moisture and prevents proper browning. Always use a cookie sheet lined with parchment paper.
Not Checking the Temperature: Invest in a good meat thermometer. You want 160°F internal temperature – no more, no less.
Forgetting to Cool the Onions: Adding hot sautéed onions to raw meat can start cooking the meat prematurely and create an uneven texture.
Storing Tips for the Recipe
Here’s how to keep this Southern meatloaf recipe fresh and delicious:
Refrigerator Storage: Wrap leftover meatloaf tightly in plastic wrap or store in an airtight container for up to 4 days. I usually slice it before storing to make it easier to grab pieces for sandwiches or quick reheating.
Freezer Storage: This meatloaf freezes beautifully! Wrap the cooled, cooked meatloaf in plastic wrap, then aluminum foil, and freeze for up to 3 months. You can also freeze individual slices wrapped separately for quick single servings.
Make-Ahead Tips: You can prepare the raw meatloaf mixture up to 24 hours ahead. Just cover and refrigerate, then shape and bake when ready. This actually improves the flavor as the seasonings have time to meld together.
Reheating Instructions: For whole slices, reheat in a 350°F oven for 10-15 minutes until warmed through. For individual slices, the microwave works fine – just cover with a damp paper towel to prevent drying out.
Meal Prep Wisdom: Every Sunday, I spend about two hours meal prepping for the week. This meatloaf is perfect for this routine because it maintains its amazing flavor and texture for several days. I often make two loaves at once – one for immediate serving and one for the freezer.
FAQs
Q: Can I make this recipe ahead of time?
A: Absolutely! Sarah from Portland asked me this same question last week. You can prepare the entire raw meatloaf up to 24 hours ahead and refrigerate it. Just add an extra 10 minutes to the cooking time if you’re baking it straight from the fridge.
Q: Why does my meatloaf fall apart when I slice it?
A: This is usually because the meat mixture is too wet or wasn’t mixed properly. Make sure your sautéed onions are completely cool before adding them, and don’t skip the resting time after baking. If your mixture seems too wet, add a few more breadcrumbs.
Q: Can I substitute the pork with something else?
A: You can use ground turkey or chicken, but you’ll lose some of that rich Southern flavor that makes this recipe special. If you do substitute, add an extra tablespoon of Worcestershire sauce for more depth.
Q: My meatloaf always comes out dry. What am I doing wrong?
A: The most common culprit is using meat that’s too lean or overcooking. Stick with 80/20 ground beef, don’t skip the pork, and use a meat thermometer to avoid overcooking. Also, make sure you’re not overmixing the meat.
Q: Can I double this recipe?
A: Definitely! I do this all the time for large gatherings. Just make two separate loaves rather than one giant one – they’ll cook more evenly that way.
Q: What’s the best way to reheat leftover meatloaf?
A: For the best texture, reheat slices in a 350°F oven for about 10 minutes. Cover with foil to prevent drying out. The microwave works in a pinch, but the oven gives better results.
Conclusion
This soulful Southern meatloaf recipe combines traditional comfort food flavors with modern cooking techniques to create a dish that’s both nostalgic and perfectly suited for today’s families. The key lies in the perfect blend of beef and pork, the aromatic vegetables, and that sweet-tangy glaze that caramelizes beautifully in the oven.
I’m absolutely thrilled to share this recipe with you – it’s become such a cornerstone of our family dinners, and I know it’ll become one of yours too. The rich flavors and tender texture make it perfect for everything from casual weeknight meals to special Sunday suppers.
Please try this recipe and share your feedback in the comments below! I read every single comment and love hearing your stories. And don’t forget to subscribe to my newsletter for more soul-warming recipes that bring families together around the dinner table. Happy cooking, y’all!